He was stretchered off after only eight minutes of QPR's home game with Cheltenham on Tuesday night with a recurrence of an ankle ligament injury.
Williams will now have a scan but it seems certain he has a recurrence of the recently healed ligament.
Williams has only recently returned to the Rangers side after he fell over a pot-hole on a practice pitch in December and suffered a rupture of the anterior fibula ligament and a substantial tear to the calcaneo fibula ligament.