Upson was replaced by Olivier Tebily 15 minutes from the end of the game at Anfield and Bruce said that he will know more on the extent of the injury in the next twenty-four hours.
"Matthew's got a calf injury which we hope is not too serious," Bruce said after the game at Anfield.
"We'll know more in the next twenty-four hours but that is a vital blow to us because he does look very sore at the moment."