The Blues wing-back limped out of the FA Cup 3rd round tie against Leeds at the beginning of the month and despite stepping up his training with a view to returning to manager Steve Bruce's squad for the game against Fulham, he has suffered a recurrence on the injury this week and will miss the game against Chris Colemans side at St Andrew's on saturday.
Bruce will also be without the services of centre-back Matty Upson as he serves a one game ban after picking up his fifth yellow card of the season against Charlton last weekend.
Martin Taylor looks the likely choice to deputise for the England international.
Blues (from): Maik Taylor, Melchiot, Martin Taylor, Cunningham, Tebily, Johnson, Carter, Clemence, Anderton, Diao, Morrison, Heskey, Blake, Yorke, Vaesen, Clapham, Gray.