The Blues keeper has been called up to the senior squad for the first time because of the withdrawal of Preston keeper Wayne Henderson through injury.
Doyle joins Blues team-mate Stephen Kelly in Steve Staunton's squad for the matches against Wales on 24th March and Slovakia four days later, both games being played at Croke Park, Dublin.
Revised Republic of Ireland squad: Shay Given (Newcastle), Nicky Colgan (Barnsley), Colin Doyle (Birmingham City), Paul McShane (West Brom), Richard Dunne (Man City), Steve Finnan (Liverpool), Ian Harte (Levante), Stephen Kelly (Birmingham City), Darren O'Dea (Celtic), John O'Shea (Man United), Kevin Kilbane (Wigan), Stephen Ireland (Man City), Lee Carsley (Everton), Jonathan Douglas (Leeds), Aiden McGeady (Celtic), Stephen Hunt (Reading), Alan Quinn (Sheffield United), Damien Duff (Newcastle), Darron Gibson (Royal Antwerp), Robbie Keane (Tottenham), Anthony Stokes (Sunderland), Kevin Doyle (Reading), Shane Long (Reading), Andy Keogh (Wolves).