Terry Westley's side will be looking to improve on their first result of the new Barclays Premier Reserves League South season having been comprehensively beaten 4-0 by Arsenal's second string at St Andrews last Tuesday evening.
The Hammers second string were also beaten in their first game of the season, Alex Dyer's side losing 2-1 against Aston Villa Reserves at Villa Park last week.
The last time Blues played West Ham at Reserve team level was on 12th February 2008 when the Hammers came from a goal behind to gain a comfortable 4-1 win at The Boleyn Ground.
Tonight's match between the two side's at The Boleyn Ground kick's off at 7pm.
West Ham Reserves: Stech, Ferrari, Daprela, N'Gala, Da Costa, Payne, Quashie, Behrami, Hines, Nouble, Diamanti. Subs: Street, Fry, Zola, Kearns, Edgar
Blues Reserves: Doyle, Joyce, Rowe, Dann, Preston, Packwood, Hubbins, Sammons, Hronec, Jervic, Ntambwe. Subs: Butland, Williams, Hawker, Dunphy.