Keith Bertschin's side go into the game against Rene Meulensteen's table-topping second string on the back of a comfortable three-nil away win against Wigan in their last Barclays Premier Reserves League (north) fixture at the end of last month.
In the corresponding fixture between the two sides last season Blues Reserves were comprehensively beaten 3-0 by their United counterparts who eventually went on to secure the 2004-05 League title.
Kick-off at St Andrew's tonight is at 7pm.
Blues: Legzdins, Mark Hall, Sadler, Oji, Campion, Alsop, Birley, Hojsted, Allen, Wright, Motteram. Subs: Hinks, Wilson, Davis, Johnson, Green.
Man United: Steele, Bardsley, K Lee, M Howard, Piqué, Gibson, Neumayr, R Jones, Campbell, Rossi, Solskjaer. Subs: Marsh, Zieler, Cathcart, Rose, Moran.