Keith Bertschin's side will be looking for their first win since the opening Reserves League fixture of the season when they travel to Hyde United FC's Ewen Field ground to take on Ricky Sbragia's Reserve League title holders.
Blues Reserves have drawn three and lost one game since they beat Sunderland Reserves at Damson Park at the beginning of August.
In the corresponding fixture last season Blues Reserves twice came from behind to take all three points from a hugely entertaining game against Manchester Utd Reserves. A Marcos Painter double and a brilliant solo effort from Julian Gray helping Keith Bertschin's side to a 3-2 success at Moss lane.
Kick-off at Hyde United FC tonight is at 7pm.