Keith Bertschin's side will host last season's league winners at Damson Park on Tuesday, 28th August.
The following week Blues Reserves play their first away game of the new season against Tottenham Hotspur at Leyton Orient's Brisbane Road ground.
The second strings' first local derby game against Aston Villa will be at St Andrew's on 3rd December with the reverse fixture at Walsall's Bescot Stadium being the final game of the season on 31st March 2006.